Use in Increasing Chemotherapy Dose Intensity

The guidelines note that there is an apparent steep dose-response curve in preclinical studies but that retrospective analyses of dose-delivered intensity in the clinic suggest that bias may have been introduced. Some of the randomized trials compared lower than standard-dose chemotherapy with standard-dose chemotherapy. In the late 1990s, trials increasing dose intensity above standard levels were not shown to improve survival. The recommendation was that outside the setting of clinical trials, the use of CSFs to increase dose intensity was not justified.

0 0

Post a comment