PEG-rHuMGDF (Amgen, Thousand Oaks, CA), is a nonglycosylated, truncated molecule produced in Escherichia coli and composed of the first 163 amino acids of the native molecule that is then chemically coupled to a 20-kDa PEG moiety (Fig. 6 and Table 2) (19). This half of the native molecule is 50% similar to EPO and contains the receptor binding domain but has a very short circulatory half-life and no biologic activity in vivo owing to the absence of the remaining, carbohydrate-rich portion of the native molecule. The addition of the PEG moiety serves to stabilize the molecule in circulation and replaces the carbohydrate domain. It has a half-life of 30-40 h (73,74).
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