Jason Gotlib MD MS and Peter L Greenberg MD



Myelodysplastic Syndromes Mechanisms of Action of EPO and G-CSF Aplastic Anemia

HGFs as Adjunctive Therapy to Immunosuppression G-CSF Therapy and the Risk of MDS/AML

Transformation in Aplastic Anemia Summary References

Myelodysplastic syndromes (MDS) and idiopathic aplastic anemia (AA) are acquired bone marrow failure states. In AA, cytopenias are primarily caused by immune-mediated destruction of stem cells and concomitant severe compromise of hematopoiesis. In low-risk MDS, excessive intramedullary apoptosis of hematopoietic progenitors and ineffective hematopoiesis often account for the paradox of hyper-cellular marrows in the setting of chronic refractory cytopenias. Evolution to acute myeloid leukemia (AML) occurs in a proportion of patients with MDS and is frequently associated with reversion of marrow myeloid precursors to a leukemic pheno-type. The development of recombinant cytokines has facilitated in vitro and in vivo analysis of the proliferative and differentiation defects involved in MDS and AA

From: Cancer Drug Discovery and Development Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics Edited by: G. Morstyn, M. A. Foote, and G. J. Lieschke © Humana Press Inc., Totowa, NJ

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