In the 1950s, pioneering studies by Erslev and others conclusively demonstrated the presence of a humoral factor capable of stimulating erythropoiesis (1,2). It was not until 1977, however, that Miyake et al. (3) isolated human erythropoietin (HuEPO) from the urine of severely anemic patients. Although preparation of the pure hormone allowed amino-acid sequencing of small EPO peptide fragments, it wasn't until 1983, with the use of unique probing strategies of a genomic library that the human EPO gene was cloned (4). In this chapter, we review the clinical pharmacology of recombinant human erythropoietin (rHuEPO), including its chemistry, pharmacologic actions, pharmacokinetics, pharmacodynamics, and activity in various patient populations. In addition, newer erythropoietic proteins, such as darbepoetin alfa, as well as some ongoing research approaches to creating other new erythropoietic molecules, are discussed.

From: Cancer Drug Discovery and Development Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics Edited by: G. Morstyn, M. A. Foote, and G. J. Lieschke © Humana Press Inc., Totowa, NJ

Fig. 1. EPO undergoes post-translational glycosylation at three specific asparagine residues (Asn24, Asn38, and Asn83) and one serine residue (Ser126).
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment