Filgrastim In The Treatment Of Breast Cancer

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Although filgrastim was known to have an effect on hematopoetic cell lines, it was not clear whether it stimulated nonhematopoetic cells or tumor cells. Several studies were done to elucidate the effect, if any, on human breast cancer cells. Emerman and Eaves (22) evaluated human breast epithelial cells from normal and malignant tissues and evaluated the effects of eight cytokines: G-CSF, GM-CSF, Steel factor, interleukin (IL)-2, IL-3, IL-6, transforming growth factor-P (TGF-P), and macrophage inflammatory protein 1-a. The authors found no effect of the cytokines on the growth of normal or malignant breast epithelial cells. Filgrastim appears to be safe in the treatment of breast cancer, but when in the course of chemotherapy is the best time for it to be given?

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