Construction And Screening Of Smallmolecule And Peptide Libraries

Cloning of hematopoietic receptors has provided targets to screen small molecules and peptides for hematopoietic agonist (7) and antagonist (8) activity. By constructing compound libraries and using high-throughput automation, hundreds of thousands of small molecules and peptides have been screened against these targets to identify, and subsequently optimize, lead molecules. Although the techniques for constructing small-molecule and peptide libraries are very different, the same types of high-throughput screening (HTS) assays (competitive binding and functional assays) are used to screen both classes of compounds.

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