Conclusions

The roles of SCF/c-kit in hematopoiesis during development and in the adult animal, and their analogous roles for other organismic processes including melanogenesis and gametogenesis, dictate that SCF/c-kit will continue to provide fertile ground for the study of mechanisms by which tissue development and homeostasis are regulated. c-Kit expression by hematopoietic stem/progenitor cells, and potentially by candidate stem cells of other adult tissues (e.g., oval cells in the liver as well as cardiac multipotential cells [202]), is also relevant to current efforts to understand the basis of adult tissue regeneration and apparent plasticity of stem cells found in various adult tissues such as bone marrow, brain, and skeletal muscle (61,202-204).

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