Animal Models Evaluating Hematopoietic Growth Factor Signaling In Pathologic Processes

The phenotypic characterization and experimental validation of the animal models included descriptions of several pathologic states such as acute inflammation or experimental infection in which the role of a particular HGF has been assessed. To understand particular nuances regarding the role of HGF signaling in disease pathogenesis, particularly at the level of the receptor, several models have been generated by targeted gene modification rather than disruption. Particularly interesting questions about the contribution of HGF to disease pathogenesis can be addressed by interbreeding two murine models together, or by exploiting the range of genetic backgrounds available and the transplantability of the hematopoietic system to assess the role of paracrine and host factor production in disease pathogenesis.

0 0

Post a comment