Holistic Treatment to get rid of Chronic Fatigue
Chronic fatigue syndrome (CFS) is often referred to by other names or used interchangeably with similar disorders, such as chronic fatigue and immune dysfunction syndrome (CFIDS), fibromyalgia (FM), myalgic encephalomyelitis (ME), Gulf War Syndrome, and chronic Epstein-Barr disease. Recently, the Centers for Disease Control (CDC) has published epidemiologic figures estimating that approximately 800,000 Americans are affected by CFS. The associated economic loss is estimated in the billions of dollars, due to disability, medical expenses, and loss of wages. CFS is an incompletely understood, yet severely disabling disease of unknown etiology. It is characterized by profound, debilitating fatigue, of greater than 6 months duration that cannot be resolved with rest. Associated symptoms include fever, sore throat, myalgias, lymphadenopathy, sleep disturbance, headaches, neurocognitive difficulties (such as memory and concentration impairment and mental fog''), and symptoms associated with...
The term chronic fatigue syndrome may be applied to a patient whose persistent tiredness lacks a physical pathology to account for it. The diagnosis of neurasthenia was popular in the late nineteenth century, and its symptoms included fatigue after minimal effort, loss of interest, irritability, poor concentration, and sleep disturbance. Similar syndromes have attracted great interest in recent years under new names such as chronic fatigue syndrome, post-viral syndrome, and myalgic encephalomyelitis (ME). There is an association with chronic pain and 'fibromy-lagia', on the one hand, and with psychiatric disturbance including anxiety and depression, on the other hand. However, there is no agreed physical basis for these conditions for example, no objective inflammation or other pathology ('-itis') of the muscles or brain has been found to justify the use of the term encephalomyelitis. Some cases follow infection with the Epstein-Barr virus (which causes infectious mononucleosis or...
Early randomised trials have compared the effectiveness of counselling with treatment as usual from the GP (Ashurst & Ward, 1983 Boot et al., 1994 Friedli et al., 1997 Harvey et al., 1998 Hemmings, 1997). More recently, randomised trials have compared counselling, cognitive-behaviour therapy (CBT) and treatment as usual (Ridsdale et al., 2001 Simpson et al., 2000, 2003 Ward et al., 2000), with patient preference conditions, and between counselling and drug treatment (Bedi et al., 2000). The patient groups taking part in these studies have included individuals assessed as suffering from moderate and chronic depression, anxiety and chronic fatigue. This set of studies has been systematically
Disease associations between HHV-6 infection and multiple sclerosis, fibromyalgia, and chronic fatigue syndrome Ablashi et al. (2005) have performed a meta-analysis of over 85 published papers in which the relationship between HHV-6 and patients with multiple sclerosis or fibromyalgia, or chronic fatigue syndrome (CFS) was examined. Although a clear causal relationship has not been established between HHV-6 and these chronic illnesses, his study discerned that there is evidence of correlation in more than 75 of those papers that distinguish between active and latent virus. Since both in vitro studies and in vivo clinical experience provide evidence that HHV-6 is immuno-suppressive, patients with a history of CFS (data provided through the courtesy of Daniel Peterson, MD) were tested for the functionality of their global T-cell response using an FDA-cleared test for cell-mediated immunity assessment (Cylex Immune Function Assay, ImmuKnowTM) and these cellular immune responses were...
Sometimes, however, if patients feel reticent about their emotional distress, the pain or the tiredness may be presented as the main problem. Depression of mood is the underlying problem in many patients given otherwise mystifying labels of 'chronic fatigue syndrome' or 'chronic pain syndrome'.
All the ginsenosids (saponins) so tested have shown antifatigue actions in mice (25). This may reflect the purported adaptogenic action of ginseng, which can be defined as an increase in resistance to stresses and is thought to be secondary to normalization of body processes through regulation of the production of various hormones (4). In evaluating the administration of Siberian ginseng for treatment of chronic fatigue syndrome, Hartz and colleagues found no measurable positive effect in those individuals receiving ginseng as compared to subjects receiving placebo (26).
In contrast to other human herpesviruses such as herpes simplex virus (HSV) or cytomegalovirus (CMV), HHV-6 has not been the subject of extensive antiviral screening, the main reason being the uncertainty about the large need for specific anti-HHV-6 therapies. Transplant recipients commonly show laboratory signs of HHV-6 reactivation, but the frequency by which this is associated with serious disease is still ill defined (Yoshikawa, 2004). Even more controversial is the role of HHV-6 in chronic neurological disorders, such as multiple sclerosis (MS) or chronic fatigue syndrome (CFS). In the absence of HHV-6-specific therapies, treatment of HHV-6 infections currently relies on the relatively broad-spectrum antiherpetic agents (val)ganciclovir and foscarnet. Although these drugs offer an indisputable benefit in the therapy or prophylaxis of CMV, their clinical efficacy against HHV-6 can only be estimated from a number of heterogeneous case reports. Long-term administration of these...
In a randomised, double-blind, placebo-controlled trial of 84 elderly subjects (aged 70-92 years) who experienced onset of fatigue after slight physical activity, l-carnitine (2 g twice daily) for 30 days resulted in significant improvements in total fat mass, total muscle mass, lipid profiles, as well as overall improvements in physical and mental fatigue (Pistone et al 2003). Animal studies have demonstrated that supplementation of carnitine (300 mg kg day) and lipoic acid (100 mg kg day) for 30 days protects mitochondria from ageing by raising mitochondrial energy production and reversing the age-associated decline in mitochondrial enzyme activity (Savitha et al 2005). Studies using standard oral doses of l-carnitine in humans are required to confirm these effects.
Bereavement, like retirement, is more likely to occur in later adulthood. Depression, sleep disturbances, loss of appetite and weight, chronic fatigue, lack of interest in external things, and difficulties in concentrating are among the symptoms of bereavement. In some cases, reactions to the death of a spouse or other close relative are so intense that severe physical illness, a serious accident, or even death may result (Parkes, 1972).
The potential therapeutic approaches for human herpesvirus-6 (HHV-6) infections include antiviral therapy and immune therapies. Several experimental therapy approaches have possible benefits for such infection based on theoretical grounds as well as clinical studies. These therapies may alter viral infection via immune-mediated mechanisms, which relate to either humoral immunity or cell-mediated immune function. There may also be direct or indirect antiviral effects. Herein, these therapy alternatives are reviewed in terms of experimental and clinical data. Most of the clinical studies regarding these therapies that have implications for patients with HHV-6 infection have generally been done in groups of patients with disease states or syndromes that are possibly associated with HHV-6 infection. The main examples of such clinical syndromes that are addressed in this section are chronic fatigue syndrome (CFS) and multiple sclerosis (MS). Diaz-Mitoma F, Turgonyi E, Kumar A, Lim W,...
A recent randomised placebo-controlled trial evaluated the effectiveness of Siberian ginseng in chronic fatigue syndrome (CFS). No significant improvements were demonstrated overall however, sub-group analysis showed improvements in fatigue in CFS sufferers with less severe fatigue (Hartz et al 2004). Further studies are required to determine whether Siberian ginseng may be a useful therapeutic option in cases of mild to moderate fatigue.
Clinically evaluated, unexplained persistent or relapsing chronic fatigue that is of new or definite onset (i.e. not lifelong), is not the result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction in previous levels of occupational, educational, social or personal activities. Together with the concurrent occurrence of four or more of the following symptoms substantial impairment in short-term memory or concentration, sore throat, tender lymph nodes, muscle pain, multi-joint pain without swelling or redness, headaches of a new type, pattern, or severity, unrefreshing sleep or postexertional malaise lasting more than 24 h, the symptoms must have persisted or
CNS demyelination 312-6 febrile seizures 214-5 HHV-6 infection 213-4, 215, 257f mesial temporal-lobe epilepsy (MTLE) 215 multiple sclerosis (MS) 215-8 progressive multifocal leukoencephalopathy (PML) 219-20 cerebral lymphomas 194 characteristic tissue reaction 140f chronic allograft nephropathy 205, 286 chronic fatigue syndrome (CFS) 86-7, 207-9, 251-2, 309
Therapeutic Uses and Folklore rosemary has been used traditionally to treat whooping cough, fluid retention, poor circulation, jaundice, migraine, mental fatigue, panic attacks, irritability, and aching joints. The Romans used it for insect bites, the Greeks used it for curing jaundice, the Arabs used it to refresh the memory, and the French used it to sanitize the air in hospitals.
Fibromyalgia, chronic fatigue syndrome (CFS), and potentially multiple sclerosis. As molecular, serological, and cellular methodologies for HHV-6's detection improve, insight into causality will provide avenues for developing prophylactic and treatment strategies for this ubiquitous virus that affects millions of individuals.
A recent double-blind, placebo-controlled, balanced crossover design of 30 healthy young adults taking P. ginseng extract (200 mg or 400 mg) or placebo, demonstrated Improvements In performance and subjective feelings of mental fatigue during sustained mental activity. It has been hypothesised that this effect may be due In part to the ability of ginseng to regulate blood glucose levels (Reay et al 2005).
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