Xpigments And Inclusions

A. Lipofuscin granules are pigmented cytoplasmic inclusions that commonly accumulate with aging. They are considered residual bodies that are deriv ed from lysosomes.

B. Melanin (neuromelanin) is blackish intracytoplasmic pigment found in the substantia nigra and locus coeruleus. It disappears from nigral neurons in patients who have Parkinson's disease.

C. Lewy bodies are neuronal inclusions that are characteristic of Parkinson s disease.

D. Negri bodies are intracytoplasmic inclusions that are pathognomonic of rabies. They are found in the pyramidal cells of the hippocampus and the Purkinje cells of the cerebellum.

E. Hirano bodies are intraneuronal, eosinophilic, rodlike inclusions that are found in the hippocampus of patients with Alzheimer's disease.

F. Neurofibrillary tangles consist of intracytoplasmic degenerated neurofilaments. They are seen in patients with Alzheimer's disease.

G. Cowdry type A inclusion bodies are intranuclear inclusions that are found in neurons and glia in herpes simplex encephalitis.

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