DNA ploidy cell proliferation and growth factor expression

There are fundamental arguments for suggesting that DNA ploidy is a reflection of some basic processes gone astray during cell proliferation. It has been suggested that DNA aneuploidy might be a consequence of cells entering the S-phase prematurely. The close association between aneuploidy and the size of the S-phase fraction (SPF) seems to suggest this. According to Wenger et al. (1993), aneuploid tumours show a virtual doubling of the S-phase fraction. Esteva et al. (2001) have claimed that...

DNA aneuploidy and cancer progression

DNA aneuploidy is often regarded as an indicator of tumour malignancy. Many early reports have indicated a high frequency of DNA aneuploidy in several human neoplasms. This has inevitably led to detailed investigations of the influence of DNA aneuploidy on cancer invasion and metastatic progression and its potential for predicting prognosis. DNA ploidy reportedly correlates with the myometrial invasion by primary endometrial carcinomas. Aneuploid primary tumours also recur more frequently as...

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DNA ploidy, SPF and cell cycle distribution were determined by image cytometry. g0g, g2m represents the ratio of cells occurring in the two cell cycle peaks. Normally only around 10 of cells are found in the G2M peak and > 10 in this peak can be regarded as indicating hyperdiploidy. DNA ploidy, SPF and cell cycle distribution were determined by image cytometry. g0g, g2m represents the ratio of cells occurring in the two cell cycle peaks. Normally only around 10 of cells are found in the G2M...

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Figure 2 DNA-PK Ku proteins in non-homologous end-joining DNA repair. This Figure is a diagrammatic representation of the involvement of DNA-dependent protein kinase DNA-PK in non-homologous end joining DNA repair. Double strand breaks DSB activate DNA-PK. Ku70 80 heterodimer is the DNA targeting regulatory subunit of DNA-PK, and by virtue of its function as a helicase participates in the resolution of aberrant DNA structures. Among cellular proteins that interact with the Ku heterodimer is the...