Large cell carcinoma

— no evidence of squamous or glandular differentiation although they probably represent undifferentiated forms of these.

— giant cell, clear cell, lymphoepithelioma-like, basaloid and neuroendocrine variants.

In primary clear cell carcinoma (rare) exclude clear cell change in squamous or adenocarcinoma, secondary thyroid, salivary or renal cell carcinoma, malignant melanoma and benign clear cell (sugar) tumour of lung (HMB-45 and glycogen positive)—a perivascular epithelioid cell tumour (PEComa)).

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