Differentiation

Well/moderate/poor/undifferentiated, or Grade 1/2/3/4. Varies according to lesion type, e.g. keratinizing squamous carcinoma is well to moderately differentiated, non-keratinizing large cell moderate and non-keratinizing small cell poorly differentiated. About 60% are moderately differentiated. Tumour grade does not reliably predict prognosis and is only broadly indicative. However, grade 1 (small amount (<10%) of solid growth with mild nuclear atypia) has a better prognosis than grade 3 (solid pattern (>50%) with severe nuclear atypia) adeno-carcinoma. Undifferentiated carcinomas show no squamous or glandular differentiation (grade 4).

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