Circumscribedirregular 2 Histological Type Adenocarcinoma

— enteric pattern, well or moderately differentiated: usual type.

— anaplastic (poorly differentiated) forms also occur more frequently than in colorectal cancer.

— mucinous carcinoma: >50% of the tumour area.

— signet ring cell carcinoma: >50 % of the tumour cells.

Diagnosis of primary small intestinal adenocarcinoma is by exclusion of spread from more common sites, e.g. colorectum and stomach. Similar to the large intestine there is some evidence for a dysplasia (adenoma)-carcinoma sequence in the adjacent mucosa. Prognosis is poor due to late presentation and advanced stage.

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