— endocervical: 70% of cervical adenocarcinomas and variably glandu-lar/mucinous related to the degree of differentiation which is usually well to moderate.

— endometrioid: 25% of cervical adenocarcinomas and exclude uterine carcinoma extending to cervix. Typically at the junctional zone arising from endometriosis/endometrial metaplasia and may coexist with usual endocervical type adenocarcinoma. A minimal deviation variant exists.

— minimal deviation (adenoma malignum): late presentation and poor prognosis with bland epithelium showing mitoses and irregular gland extension deep (>50%) into the cervical stroma. CEA and p53 overexpression may be of diagnostic help. Associated with Peutz-Jeghers syndrome.

— villoglandular: good prognosis in young females. Papillary with CGIN type epithelium, connective tissue cores and indolent invasion at base. More aggressive, moderately differentiated variants occur and it can be associated with more usual cervical cancer subtypes. Also consider implantation from an endometrial primary.

— clear cell: clear, hobnail cells, glycogen PAS positive, solid, tubules, papillae; in utero exposure to diethylstilboestrol (50%).

— serous papillary: poor prognosis and potentially multifocal in endometrium and ovary. High-grade cytological appearances ± psam-moma bodies—exclude low-grade villoglandular carcinoma.

— mesonephric: from mesonephric duct remnants deep in the posterior or lateral cervical wall. Small glands with eosinophilic secretions.

— non-Mullerian mucinous: intestinal including colloid and signet ring cell carcinomas. Poor prognosis and exclude gut secondary.

Was this article helpful?

0 0
How To Prevent Skin Cancer

How To Prevent Skin Cancer

Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.

Get My Free Ebook

Post a comment