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We will describe the technologies being developed to circumvent the barriers encountered in delivering chemotherapeutics to the central nervous system. Special emphasis will be placed on the development of the FDA-approved BCNU-loaded polymer (Gliadel®) for the treatment of malignant tumors. This chapter will review the results and implications of pre-clinical and clinical studies of Gliadel® and other polymer-chemotherapeutic agent systems and describe the surgical technique used to implant Gliadel® wafers at the tumor site. Finally, we will address future directions of local drug delivery for treating brain tumors.
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