Conclusions

Treatment of malignant gliomas has proven to be very challenging. As discussed, difficulties with systemic chemotherapy and the high local recurrence rate of primary tumors have effectively driven the need for interstitial chemotherapy and polymer drug delivery. Biodegradable polymers can provide controlled, prolonged local delivery of anti-neoplastics, and these polymers allow for highly customizable release times and multiple formulation modalities. In addition to the ongoing clinical trials, exciting new data are emerging from the laboratory involving various therapeutics, combination therapeutics, and innovative delivery modalities to decrease mortality caused by malignant brain tumors.

figure 19.7 (A) Microchip on a quarter and compared to a pencil tip (photo by Carita Stubbe, courtesy of MicroCHIPS, inc.). The dots between the three large bars (cathodes) on the front are the caps (anodes) covering the reservoirs holding the chemicals. Electrical voltage applied between the cap and cathode causes a reaction that dissolves the cap, thus releasing the reservoir's contents. The back view shows the larger opening through which the content of the reservoirs are deposited. (Reprinted with permission) [119]. (B) Schematic of the passive microchip. Initial models will use PLGA and other existing polymer matrices for the substrate. The entire chip will be biodegradable. (Reprinted with permission) [119]. See Plate 19.7 in Color Plate Section.

b figure 19.7 (A) Microchip on a quarter and compared to a pencil tip (photo by Carita Stubbe, courtesy of MicroCHIPS, inc.). The dots between the three large bars (cathodes) on the front are the caps (anodes) covering the reservoirs holding the chemicals. Electrical voltage applied between the cap and cathode causes a reaction that dissolves the cap, thus releasing the reservoir's contents. The back view shows the larger opening through which the content of the reservoirs are deposited. (Reprinted with permission) [119]. (B) Schematic of the passive microchip. Initial models will use PLGA and other existing polymer matrices for the substrate. The entire chip will be biodegradable. (Reprinted with permission) [119]. See Plate 19.7 in Color Plate Section.

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