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FIGURE 19.6 (A) Kaplan-Meier survival curve for patients with initial therapy for Grade II and Grade IV gliomas treated with BCNU-loaded polymer implants versus placebo. (Reprinted with permission from Lippincott Williams & Wilkins) [65]. (B) Kaplan-Meier survival curve depicting the results of the Valtonen and Westphal Phase III studies evaluating the local delivery of GliadelĀ® (3.8 per cent BCNU polymer) in patients with high grade malignant glioma.

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