Myelin Water Fraction

Myelin Water Fraction

Although the specificity of T1 and T2 measurements are generally perceived as being poor, several investigators have recently shown that the T2 signal decay in neural tissue is multi-exponential with echo time (Menon and Allen 1991 MacKay et al. 1994 Whittall et al. 1997). Further investigation has shown that different water tissue compartments each have distinct T2 characteristics, and may be separated (see Fig. 24). In white matter, the water signal compartments are believed to originate from...