Word Key

Acidosis • Increase in the acidity of blood (as in diabetic acidosis) due to an excessive loss of bicarbonate (as in renal disease)

Alkalosis • Increase in blood alkalinity due to an accumulation of alkaline or reduction in acid Allosteric • Shape change

Amino acid • One of a large group of organic compounds marked by the presence of both an amino group (NH2) and a carboxyl group (COOH); the building blocks of protein and the end products of protein digestion

Complement • Group of proteins in the blood that play a vital role in the body's immune defenses through a cascade of interaction

Cyanosis • Blue tinge to the extremities (lips, fingers, toes) Hyperplasia • Excessive proliferation of normal cells in the normal tissue of an organ

Polychromasia • Blue tinge to the red cells indicating premature release

References

1. Brown BA. Hematology: Principles and Procedures, 6th ed. Philadelphia: Lippincott Williams and Wilkins, 2003;42-43.

2. Turgeon ML. Normal erythrocyte lifecycle and physiology. In: Turgeon ML, ed. Clinical Hematology: Theory and Procedures, 3rd ed. Philadelphia: Lippincott Williams and Wilkins, 1999; 66.

3. Ludvigsen FB. Hemoglobin synthesis and function.

In: Steine-Martin EA, Lotspeich-Steininger CA, Koepke JA, eds. Clinical Hematology: Principles, Procedures and Correlations, 2nd ed. Philadelphia: Lippincott, 1998; 75.

4. Hillman RS, Finch CA. General characteristics of the erythron. In: Hillman R, Finch C, eds. Red Cell Manual, 7th ed. Philadelphia: FA Davis, 1996; 17-19.

5. Harmening DM, Hughes VC, DelToro C. The red blood cell: Structure and function. In: Harmening D, ed. Clinical Hematology and Fundamentals of Hemo-stasis, 4th ed. Philadelphia: FA Davis, 2002; 66-67.

6. Bunn HF Human hemoglobins: Normal and abnormal: Methemoglobinemia. In: Nathan SH, Oski A, eds. Hematology of Infancy and Childhood, 4th ed. Philadelphia: WB Saunders, 1993; 720-723.

7. Wright MS, Smith LA. Laboratory investigation of autoimmune hemolytic anemias. Clin Lab Sci 12:119-122, 1999.

8. Nemchik L. Introduction to anemias of increased erythrocyte destruction. In: Steine-Martin EA, Lotspeich-Steininger CA, Koepke JA, eds. Clinical Hematology: Principles, Procedures and Correlations, 2nd ed. Philadelphia: Lippincott, 1998; 245.

9. Ucar K. Clinical presentation and management of hemolytic anemias. Oncology 10:163-170, 2002.

10. Birch D. Malaria: Quest for a Vaccine. Baltimore Sun, June 18,2000.

11. Lemery L, Ciesla B. Why Did this Sample Fail the Correlation Checks? American Society of Clinical Pathologists Tech Sample 1997 G-12. Chicago, Ill.

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