Word Key

Autoimmune hemolytic anemia • Process by which cells fail to recognize self and consequently make antibodies that destroy selected red cells

Direct antiglobulin test • Laboratory test for the presence of complement or antibodies bound to a patient's red blood cells

Erythroderma • Abnormal widespread redness and scaling of the skin, sometimes involving the entire body Monosomy • Condition of having only one of a pair of chromosomes, as in Turner's syndrome, where there is only one X chromosome instead of two Pathognomonic • Indicative of the disease Raynaud's phenomenon • Intermittent attacks of pallor or cyanosis of the small arteries and arterioles of the fingers as a result of inadequate arterial blood supply Plasmapheresis • Plasma exchange therapy, involving the removal of plasma from the cellular material that is then returned to the patient

Rouleaux • Group of red cells stuck together that look like a stack of coins

Translocations • Alteration of a chromosome through the transfer of a portion of it either to another chromosome or to another portion of the same chromosome

References

1. Cutler S J, Axtell L, Hesiett H. Ten thousand cases of leukemia 1940-62. J Natl Cancer Inst 39:993, 1967.

2. Dohner H, Stilgenbauer S, Beuner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 343:1910-1916, 2000.

3. Redaelli A, Laskin BL, Stephens JM, et al. The clinical and epidemiological burden of chronic lymphocytic leukemia. Eur J Cancer Care 13:279-287, 2004.

4. McConkey DJ, et al. Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and related expression of BCL-2 and BAX. J Immunol 156:2624, 1996.

5. Holmer LD, Hamoudi W, Bueso-Ramos CD. Chronic leukemia and related lymphomproliferative disorders. In:

Harmening D, ed. Clinical Hematology and Fundamentals of Hemostasis, 4th ed. Philadelphia: FA Davis, 2002: 303.

6. McFarlandJT, Kuzma C, Millard FE, et al. Palliative irradiation of the spleen. Am J Clin Oncol 25:178-183, 2003.

7. Rosenwald A, Chuang EY, Dabis RE, et al. Fludara-bine treatment of patients with CLL induces a p53-dependent gene expression response. Blood 104: 1428-1434,2004.

8. Bradford C. Cytochemistry. In: Rodak B, ed. Hematology: Clinical Principles and Applications, 2nd ed. Philadelphia: WB Saunders, 2002: 391.

9. Jenn U, Bartl R, Dietzfelbinger H, et al. An update:

12 Year follow-up of patients with hairy cell leukemia following treatment with 2-chlorodeoxyadenosine. Leukemia 18:1476-1481, 2004.

10. Turgeon ML. Malignant lymphoid and monocytic disorders and plasma cell dyscrasias. In Turgeon ML, ed. Clinical Hematology: Theory and Principles, 4th ed. Baltimore: Lippincott Williams & Wilkins, 2005: 287.

11. Manner C. The lymphomas. In Steine-Martin EA, Lotspeich-Steininger CA, Keopke J, eds. Clinical Hematology: Principles, Procedures, Correlations, 2nd ed. Baltimore: Lippincott Williams & Wilkins, 1998: 490-497.

12. Bergsagel DE, Wong O, Bergsagel PL, et al. Benzene and multiple myeloma: Appraisal of the scientific evidence. Cancer Invest 18:467, 2000.

13. Dewald GW, Kayle RA, Hicks GA, et al. The clinical significance of cytogenetic studies in 100 patients with MM, plasma cell leukemia or amyloidosis. Blood 66:380-390, 1985.

14. Shaughnessy J, Jacobsin J, Sawyer J, et al. Continuous absence of metaphase-defined cytogenetic abnormalities, especially of chromosome 13 and hypodiploidy, ensures long-term survival in multiple myeloma treated with Total Therapy I: Interpretation in the context of global gene expression. Blood 101:3849-3854, 2003.

15. Multiple myeloma. Available at http://www.mayoclinic. com/health/multiple-myeloma/DS00415 from the Mayo Clinic. Accessed September 25, 2006.

218 Part III • White Cell Disorders

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