Review Questions

1. The primary inhibitor of the fibrinolytic system is:

a. antiplasmin.

c. antithrombin.

2. Dilute Russell's Viper Venom test (dRVVT) is helpful in the diagnosis of:

b. factor VIII inhibitor.

c. lupus anticoagulant.

3. The lupus anticoagulant is directed against:

a. phospholipid-dependent coagulation tests.

b. factor VIII.

c. fibrinogen.

d. vitamin K-dependent clotting factors.

4. Which statement is correct regarding Coumadin?

a. It is used for the treatment of bleeding disorders.

c. It is used for a short-term therapy.

d. It acts on vitamin K-dependent clotting factors.

5. Which statement is correct regarding protein C?

a. It is a cofactor to protein S.

b. Its activity is inhibited by heparin.

c. It forms a complex with antithrombin.

d. It is a physiological inhibitor of coagulation.

6. Activated protein C resistance is associated with:

a. mutation of factor VIII.

b. deletion of factor VI.

c. mutation of factor V.

d. deletion of factor VIII.

7. Thrombin-thrombomodulin complex is necessary for:

a. activation of protein C.

b. activation of antithrombin.

c. activation of protein S.

d. activation of factors V and VIII.

8. Heparin-induced thrombocytopenia is caused by:

a. antibody to platelet factor 4.

b. antibody to heparin-platelet factor 4 complex.

c. lupus anticoagulant.

d. antibody to heparin.

9. Which of the following drugs would put an individual at risk for thrombosis?

a. Aspirin b. Dipyridamole c. Streptokinase d. Oral contraceptives

10. Which of the following results are correct regarding lupus inhibitors?

a. Prolonged aPTT on undiluted plasma and 1:1 mix of patient plasma with normal plasma b. Corrected aPTT on a 1:1 mix of patient plasma with normal plasma after 2 hours' incubation c. Normal undiluted aPTT and prolonged aPTT on a 1:1 mix of patient plasma with normal plasma d. Normal undiluted aPTT and 1:1 mix of patient plasma with normal plasma

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