Review Questions

1. Which one of the following is the predominant red cell morphology in patients with MDS?

a. Schistocytes b. Macrocytes c. Target cells d. Bite cells

2. Which one of the MDS groups has the best prognosis?

a. MDS with excess blasts b. Refractory anemia with ringed sideroblasts c. Refractory anemia d. 5q deletion

3. What is considered a significant number of ringed sideroblasts in the MDS classification?

4. Which mechanism accounts for the reticulocy-topenia seen in most cases of MDS?

a. Heavy blast tumor burden in the marrow b. Effects of toxins c. Marrow aplasia d. Ineffective erythropoiesis

5. What is the cutoff blast count used to distinguish a patient with MDS as opposed to a patient with acute leukemia?

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