Red Blood Cell Production, Function, and Relevant Red Cell Morphology
Basic Red Cell Production Red Cell Maturation Red Cell Terminology
Maturation Stages of the Red Cell
Orthochromic Normoblast-Nucleated (nRBC)
Mature Red Cell
Red Blood Cell Membrane Development and Function
Composition of Lipids in the Interior and Exterior Layers
Composition of Proteins in the Lipid Bilayers The Cytoskeleton
Red Cell Metabolism
Abnormal Red Cell Morphology
Variations in Red Cell Size Variations in Red Cell Color Variations in Red Cell Shape
Red Cell Inclusions
After completing this chapter, the student will be able to:
1. Outline erythropoietic production from origin to maturation with emphasis on stages of red cell development.
2. Describe immature red cells with regard to nucleus:cytoplasm ratio, cytoplasm, nuclear structure, and size.
3. Clarify the role of erythropoietin in health and disease.
4. Differentiate between American Society of Clinical Pathology and College of American Pathol-ogists terminology for the red cell series.
5. Review red cell metabolism with regard to energy needs.
6. Describe the composition of the red cell membrane with regard to key proteins and lipids.
7. Describe the components necessary for maintaining a normal red cell life span.
8. Outline the plasma factors that affect red cell life span.
9. Define anisocytosis and poikilocytosis.
10. Differentiate between microcyte and macrocyte.
11. Indicate the clinical conditions in which variations in size are seen.
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