Objectives

After completing this chapter, the student will be able to:

1. Define the common features of the chronic lymphoproliferative disorders.

2. Describe the symptoms, peripheral smear morphology, and treatment of individuals with chronic lymphocytic leukemia.

3. Evaluate the complications of chronic lympho-cytic leukemias with respect to immunocompe-tency and bone marrow involvement.

4. Describe the pertinent features of hairy cell leukemia to include clinical presentation, peripheral smear, and pertinent cytochemical stains.

5. Define the clinical features of Sezary syndrome.

6. List the morphological features of the plasma cell.

7. Describe the basic immunoglobulin unit.

8. List the laboratory criteria used to diagnose the monoclonal gammopathies.

9. Differentiate the clinical and laboratory features that distinguish multiple myeloma and Waldenstrom's macroglobulinemia.

10. List the CD markers used to differentiate B-cell and T-cell disorders.

11. Compare and contrast the clinical and laboratory features of multiple myeloma and Walden-strom's macroglobulinemia.

12. Briefly describe how molecular diagnostics aid in the diagnosis of lymphoid malignancies.

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