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Microspherocyte

Intrinsic Abnormalities

Deficiency of spectrin, Uncoupling ol ankyrin or band 3 lipid bilayer and skeleton

Spherocyte forms as surface area decreases surface area decreases

Microvesicle formation leading to membrane loss

Hereditary spherocytosis

Immune Hemolysis

Antibodies attach to red cell

Spherocyte forms from fragmented membrane

Immune Hemolysis

Spherocyte forms from fragmented membrane

Antibodies attach to red cell

Fc receptor binds to antibody

Antigen-antibody complex, fragmenting red cell membrane

Figure 7.2 Three mechanisms of spherocyte formation.

Fc receptor binds to antibody

Antigen-antibody complex, fragmenting red cell membrane

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