N

Î

HH, hereditary hemochromatosis; IDA, iron deficiency anemia; SA, sideroblastic anemia; AOI, anemia of inflammation; ACD, anemia of chronic disease.

minor

HH, hereditary hemochromatosis; IDA, iron deficiency anemia; SA, sideroblastic anemia; AOI, anemia of inflammation; ACD, anemia of chronic disease.

80 Part II • Red Cell Disorders

Table 5.12 O Diagnostic Clues for the Thalassemic Conditions

If you are suspecting the two- or three-gene deletion alpha thalassemic state

• The MCVs are much lower than in IDA

• RDW is much more severe in alpha thalassemias

If you suspect the silent carrier alpha thalassemic state

• MCV is in normal or low-normal range

• Presence of elliptocytes on the smear is an indicator If you suspect beta thalassemia major state

• High numbers of nRBCs on smear

• Presence of targets, fragments on smear

• Microcytosis and hypochromia

• Hgb F is major hemoglobin on electrophoresis

If you suspect beta thalassemia minor state

• RBC count is elevated

• Microcytosis and hypochromia

• May see basophilic stippling, targets on smear

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