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Patient's blood has antibodies to EDTA.

The IgG antibody is directed against the glycoprotein complex on the platelet.

: | The antibody-coated i J platelets attach to ' 1 bands, segmented ! = neutrophils, and : ^ rarely monocytes.

The attached platelets are not counted by hematology instruments, leading to falsely low counts.

The attached platelets are not counted by hematology instruments, leading to falsely low counts.

The IgG antibody is directed against the glycoprotein complex on the platelet.

: | The antibody-coated i J platelets attach to ' 1 bands, segmented ! = neutrophils, and : ^ rarely monocytes.

As seen in peripheral smear

Figure 10.19 Platelet satellitism formation. An unexpected reaction of the patient to the EDTA causes the platelets to ring around segmented neutrophils.

seen in degenerated neutrophils as the segmented nucleus becomes an amorphous, smooth blob-like structure with no clear segmented structure. These cells are not counted in the white cell differential.

Student Challenge

Observe Figure 10.20. Is the cell at the arrow a lymphocyte or an nRBC? Why or why not?

Figure 10.20 Is this a lymphocyte or an nRBC?

As seen in peripheral smear

Figure 10.19 Platelet satellitism formation. An unexpected reaction of the patient to the EDTA causes the platelets to ring around segmented neutrophils.

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