Conditions Associated With.
Decreased Reticulocyte Count
1. Aplastic anemia
2. Exposure to radiation or radiation therapy
3. Chronic infection
4. Medications such as azathioprine, chloramphenicol, dactinomycin, methotrexate, and other chemotherapy medications
5. Untreated pernicious anemia/megaloblastic anemia
Increased Reticulocyte Count
1. Rapid blood loss
2. High elevation
3. Hemolytic anemias
4. Medications such as levodopa, malarial medications, corticotrophin, and fever-reducing medications
1. Recent blood transfusion can interfere with accurate reticulocyte results.
2. Mishandling, contamination, or inadequate refrigeration of the sample can interfere and cause inaccurate test results.
3. Red cell inclusions such as Heinz bodies, side-rocytes, and Howell-Jolly bodies can be mistaken for reticulocytes. If these are counted as reticulocytes, they will falsely increase the reticulocyte count. Inclusions should be confirmed with Wright's stain.
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