Part III • White Cell Disorders changes, nuclear bridging, macrocytes, and dimorphism.

Dysgranulopoietic changes include abnormal granulation of mature cells, hypersegmenta-tion, hyposegmentation, or complete lack of granulation.

Dysthrombopoietic changes include micro-

megakaryocytes, abnormal granulation, no granulation, and giant platelets.

The blast count in the MDS is less than 20%. Weakness, infections, and easy bruising are some of the symptoms that patients with MDS may manifest. According to the World Health Organization, there are six classifications of MDSs.

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