Renal dialysis,


blood transfu-

blood transfu-

MHA, microangiopathic hemolytic anemia.


Thrombocytosis is defined as a platelet count greater than 450 X 109/L. The cause for an increased platelet count may be primary or secondary. A primary throm-bocytosis is seen in the myeloproliferative disorders (see Chapter 12), in which case platelets are high in number but have an impaired function. Of all of the myelopro-liferative disorders, essential thrombocythemia has the highest platelet value, at times exceeding 1 million platelets. Secondary causes of thrombocytosis include acute and chronic blood loss, chronic inflammatory diseases, postsplenectomy, and iron deficiency anemia. In these cases, the platelet function is normal, although the increase in platelet numbers may last days to weeks. In severe iron deficiency anemia, the platelet count may increase to 2 million, as a result of marrow stimula-tion.13 Once iron therapy is initiated, the platelet count usually returns to normal.

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