Princess Prince Prince Prince Anne Charles Andrew Edward

Normal male


Normal female

Hemophilic male


Carrier female

Male died in infancy.

probably hemophilc

Juan Carlos of Spain oooo

Figure 17.1 Queen Victoria carried the abnormal gene for thalassemia and passed it through her offspring into the Russian royal family, the Spanish dynasty, and the German royal family.




Autosome #5

vWF monomers vWF polymer

Factor VIII Complex

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