Chronic Eosinophilic Leukemia

CEL is a chronic myeloproliferative disease characterized by an elevation and proliferation of the eosinophil.1 The eosinophil is increased in the peripheral blood, bone marrow, and peripheral tissue. There is tissue and organ damage from the overproduction of eosinophils. The diagnosis of CEL is made if the blood eosinophil count is greater than 1500/pL, there are no other causes of increased eosinophils, and there are clinical signs and symptoms of organ damage. There is no Ph chromosome or BCL-ABL fusion gene found.

Synonyms include hypereosinophilic syndrome (HES).

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