Chapter

Overview of Hemostasis and Platelet Physiology, 229

Donna Castellone

History of Blood Coagulation, 230 Overview of Coagulation, 230 Vascular System, 231

Overview, 231

Mechanism of Vasoconstriction, 231 The Endothelium, 231 Events Following Vascular Injury, 231 Primary Hemostasis, 232

Platelets: An Introduction, 232 Platelet Development, 232

Platelet Structure and Biochemistry, 232 Platelet Function and Kinetics, 233 Platelet Aggregation Principle, 234 Secondary Hemostasis, 235 Classification of Coagulation Factors, 235 Physiological Coagulation (In Vivo), 237 Laboratory Model of Coagulation, 237 Extrinsic Pathway, 237 Intrinsic System, 238 Activated Partial Thromboplastin

Time, 238 Common Pathway, 238 Formation of Thrombin, 238 Feedback Inhibition, 239 Fibrinolysis, 239 Coagulation Inhibitors, 240 Kinin System, 240 Complement System, 240

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