At Heparin

Figure 19.2 Effect of antithrombin on serine proteases.

Heparin Cofactor II

Heparin cofactor II is another coagulation inhibitor. It acts against thrombin, and it is heparin dependent. Heparin cofactor deficiency alone is not associated with thrombosis.1

Protein S is a vitamin K-dependent protein made in the liver that is necessary for activation of protein C. Once protein C is activated, it will deactivate cofactors Va and Villa. Deficiencies of proteins C and S are associated with thrombosis.

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