Revised Coagulation Cascade: In Vivo Vessel injury

Cross Linked Fibrin

Insoluble monomer cross-linked fibrin

Figure 15.5 In vivo coagulation cascade.

Insoluble monomer cross-linked fibrin

Laboratory Model of Coagulation

Laboratory testing looks at the in vitro effect of the coagulation process which is measured by the prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrin degradation products (FDPs), and D-dimer. This section will focus on PT and a PTT, while Chapter 20 will concentrate on the other routine tests mentioned. While the coagulation cascade does not reflect what goes on in vivo, it provides a model in which the laboratory relates to for testing. However, the coagulation cascade reflects the mechanisms that the laboratory uses for results. The screening tests provide a tremendous amount of information to the physician. They can be performed both quickly and accurately (Fig. 15.6).

Extrinsic Pathway

The extrinsic pathway is initiated by the release of tissue thromboplastin that has been expressed after damage to aPTT (Heparin therapy) INTRINSIC SYSTEM Contact activation pathway

Was this article helpful?

0 0
The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

Are Constant Headaches Making Your Life Stressful? Discover Proven Methods For Eliminating Even The Most Powerful Of Headaches, It’s Easier Than You Think… Stop Chronic Migraine Pain and Tension Headaches From Destroying Your Life… Proven steps anyone can take to overcome even the worst chronic head pain…

Get My Free Audio Book

Post a comment