Reticular Formation

Scattered throughout the medulla oblongata, pons, and midbrain is a complex network of nerve fibers associated with tiny islands of gray matter. This network, the reticular formation (re-tik'u-lar for-ma'shun) or reticular activating system, extends from the superior portion of the spinal cord into the diencephalon (fig. 11.21). Its intricate system of nerve fibers connects centers of the hypothalamus, basal nuclei, cerebellum, and cerebrum with fibers in all the major ascending and descending tracts.

When sensory impulses reach the reticular formation, it responds by activating the cerebral cortex into a state of wakefulness. Without this arousal, the cortex remains unaware of stimulation and cannot interpret sensory information or carry on thought processes. Thus, decreased activity in the reticular formation results in sleep. If the reticular formation is injured and ceases to function, the person remains unconscious, even with strong stimulation. This is called a comatose state.

A person in a persistent vegetative state is occasionally awake, but not aware; a person in a coma is not awake or aware. Sometimes following a severe injury, a person will become comatose and then gradually enter a persistent vegetative state. Coma and persistent vegetative state are also seen in the end stage of neurode-generative disorders such as Alzheimer disease; when there is an untreatable mass in the brain, such as a blood clot or tumor; or in anencephaly, when a newborn lacks higher brain structures.

The reticular formation also filters incoming sensory impulses. Impulses judged to be important, such as those originating in pain receptors, are passed on to the cerebral cortex, while others are disregarded. This selective action of the reticular formation frees the cortex from what would otherwise be a continual bombardment of sensory stimulation and allows it to concentrate on more significant information. The cerebral cortex can also activate the reticular system, so intense cerebral activity tends to keep a person awake. In addition, the reticular formation regulates motor activities so that various skeletal muscles move together evenly, and it inhibits or enhances certain spinal reflexes.

Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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