unit four

Shier-Butler-Lewis: I IV. Transport I 14. Blood I I © The McGraw-Hill

Human Anatomy and Companies, 2001

Physiology, Ninth Edition


Extrinsic Clotting Mechanism

Intrinsic Clotting Mechanism


Damage to vessel or tissue

Blood contacts foreign surface


Tissue thromboplastin

Hageman factor

Series of reactions involving several clotting factors and calcium ions (Ca+2) lead to the production of:

Prothrombin activator

Prothrombin activator

Prothrombin activator and calcium ions cause the conversion of:

Prothrombin to thrombin

Prothrombin to thrombin

Thrombin causes fragmentation, then joining of:

Fibrinogen to fibrin

Fibrinogen to fibrin

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