Organogermanes

Immobilized PLE was applied to promote stereoselective acetylation of prochiral bis(hydroxymethyl)methyl-phenylgermane 106 (R1 = Me) with vinyl acetate as a solvent and acyl donor.117 Later on, the same group reported that each enan-tiomer of hydridogermane monoacetates 107 (R1 = H) was obtained either via acetylation of the bis-hydroxy derivative 106 (R1 = H) or hydrolysis of the corresponding diacetate 108 (R1 = H). In both methods, porcine pancreatic lipase was used and, obviously, each reaction led to a different enantiomer of 107 (Equation 51).118

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