Fig. 5.6 (continued)

Fig. 5.6 (continued)

detailed knowledge of individual proteins, which for many studies may be essential. The principal techniques are to use software programs designed for the determination of modifications and mutations. In addition, de novo sequencing techniques are now available, which can be assisted by homology searches using MS BLAST.

The extent, size, and number of data files generated in proteomics projects is continually increasing. Several projects have to be managed and compared, and relations to other results using even different methods such as gene expression measurements are desired. For these purposes, relational databases based on Microsoft SQL or Oracle software are now on the market. The systems perform archival and retrieval of data and comparison of datasets; by using XML as a universal data exchange format, they can interface with databases outside the MS world.

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