In a double-blind RCT 37 patients received a TPN solution with or without synthetic alanyl-glutamine dipeptide (0.5 g/kg) for 5 days following major abdominal surgery. The results indicated improved nitrogen economy and a reduction in the length of hospital stay with a resulting reduction in costs (Mertes et al 2000). Reduced oral pain and inflammation has been observed in patients receiving radiation and chemotherapy during bone marrow transplantation who are taking 1 g glutamine four times daily (Miller 1999).

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