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A preliminary study investigated the effects of randomly assigned methyl- and cyanocobalamin on arcadian rhythms, wellbeing, alertness and concentration after 14 days in 20 healthy subjects (Mayer et al 1996).

Methylcobalamin supplementation led to a significant decrease in daytime melatonin levels, improved sleep quality, shorter sleep cycles, increased feelings of alertness, better concentration, and a feeling of waking up refreshed in the morning. It appeared that methylcobalamin was significantly more effective than cobalamin.

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