Shinomiya et al found that 300 mg/kg of chamomile extract significantly decreased sleep latency in a sleep-disturbed rat model (2005). Extracts of chamomile showed sedative activity on the mouse CNS (Delia Loggia et al 1981), and extracts of chamomile, as well as isolated apigenin, have been shown to bind to benzodiazepine receptors in vitro. Apigenin showed antianxiety and sedative activity with intraperitoneal injection in mice (Viola etal 1995).
Ovariectomised rats given inhalations of chamomile oil showed decreased levels of stress-induced ACTH levels compared with controls; the experiment suggested an activity similar to benzodiazepine agonists (Yamada et al 1996).
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