Folate has been Implicated in the causality of schizophrenia since the 1950s and aberrations of one-carbon metabolism were proposed as a distinct hypothesis at around the same time (Regland 2005). With our current knowledge linking the two there has been renewed interest in the role of folate in this disorder. One key issue relates to a controversial association between low folate levels and schizophrenia incidence (Muntjewerff & Blom 2005). A review of seven case-control studies concluded that three of these demonstrated a relationship, although overall the evidence was undermined by methodological shortcomings (Muntjewerff & Blom 2005). In spite of this, elevated homocysteine and a high incidence of the MTHFR C677T genotype are reportedly frequent findings in this population (Kemperman et al 2006, Regland 2005), with several case reports of success using 1 5-30 mg folate in combination with B12 injections (1 mg every 10 days) and N-acetyl cysteine (200 mg twice daily) (Regland 2005).
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