Baicalein inhibited angiotensin ll-induced increases in the cellular protein content of aortic smooth muscle cells in vitro (Natarajan et al 1994). In another in vitro study, baicalein prevented the angiotensin ll-induced increase in renal vascular resistance by 50% and promoted glomerular filtration rate (Bell-Quilley et al 1993). Pretreatment with baicalein significantly inhibited a decrease in nephrotoxin-induced glomerular filtration rate and renal blood flow in vivo (Wu et al 1993). Oral intake of baical flavonoids and extract has been shown to produce a diuretic effect.
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