A number of studies have confirmed that consumption of high-dose FSO reduces endothelium inflammation. One study assessing the cardiovascular effects of a diet in which 6.5% of total kilocalorie intake was contributed by ALA and compared with the Standard American Diet (SAD) showed that the ALA-enriched diet produced a 75% reduction in C-reactive protein, a 19% reduction in cellular adhesion molecule, and a 1 5.6% reduction in vascular cellular adhesion molecule (VCAM) (Zhao et al 2004). An earlier study had reported these findings, demonstrating a 28% reduction in VCAM with additional reductions in soluble E-selectin (17%) (Thies et al 2001).
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