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An 8-week, randomised, double-blind study found that 200 mg/day ginseng (n = 1 5, placebo: n = 1 5) improved aspects of mental health and social functioning after 4 weeks' therapy but that these differences disappeared with continued use (Ellis &

Reddy 2002). A review of eight clinical studies with ginseng found some improve- Ginseng_Korean 561

ment in QOL scores. However, the findings were equivocal. Despite some positive

results, Improvement In overall health-related QOL cannot, given the current research, be attributed to P. ginseng. However, the possibility that various facets of QOL may have Improved and the potential of early transient effects cannot be discounted (Coleman et al 2003). A double-blind, placebo-controlled, randomised clinical trial of 83 subjects also did not find ginseng to enhance psychological wellbelng In healthy young adults (Cardinal & Engels 2001).

A double-blind, placebo-controlled crossover study found that 1200 mg ginseng was only slightly more effective than placebo and not as effective as a good night's sleep In Improving bodily feelings, mood and fatigue In 12 fatigued night nurses. Volunteers slept less and experienced less fatigue but rated sleep quality worse after ginseng administration (Hallstrom et al 1982).

A recent double-blind, placebo-controlled, balanced crossover design of 30 healthy young adults taking P. ginseng extract (200 mg or 400 mg) or placebo, demonstrated Improvements In performance and subjective feelings of mental fatigue during sustained mental activity. It has been hypothesised that this effect may be due In part to the ability of ginseng to regulate blood glucose levels (Reay et al 2005).

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