Vitamin B6 supplementation is used in doses beyond RDI levels for the treatment of PMS. A 1999 systematic review of nine clinical trials involving 940 patients with PMS support this use, finding that doses up to 100 mg/day are likely to be of benefit in treating symptoms and PMS-related depression (Wyatt etal 1999). Comparative study One randomised double-blind study compared the effects of pyridoxine (300 mg/day), alprazolam (0.75 mg/day), fluoxetine (10 mg/day) or propranolol (20 mg/day) in four groups of 30 women with severe PMS (Diegoli et al 1998). In this study, fluoxetine produced the best results (a mean reduction of 65.4% in symptoms) followed by propanolol (58.7%), alprazolam (55.6%), pyridoxine (45.3%) and placebo (39.4-46.1%). Symptoms responding well to pyridoxine were tachycardia, insomnia, acne and nausea (Diegoli et al 1998).
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