Safety has not been scientifically established. PRACTICE POINTS/PATIENT COUNSELLING
• Grapeseed extract has considerable antioxidant activity and appears to regenerate alpha-tocopherol radicals to their antioxidant form.
• Grapeseed extract also has anti-inflammatory actions, reduces capillary permeability, enhances dermal wound healing and reduces photo-damage, inhibits platelet aggregation and may enhance rhodopsin regeneration or content in the retina.
• It is popular in Europe as a treatment forvenous insufficiency and capillary fragility, both of which are supported by clinical evidence. It is also used to relieve eye strain, stabilise diabetic retinopathy and connective tissue disorders.
• Preliminary research has identified cardioprotective effects due to a variety of mechanisms. Possible benefits in pancreatitis and multi-organ protection against
damage caused by several pharmaceutical drugs. Antlcarclnogenlc activity has also been reported.
• Most clinical research has been conducted in Europe with a commercial grapeseed product known as Endotelon'®.
• Due to concerns with bioavailability, it is recommended that only preparations containing low-molecular-weight PCs be used.
ANSWERS TO PATIENTS' FREQUENTLY ASKED QUESTIONS
What will this herb do for me?
There is evidence that GSE is a useful treatment for venous insufficiency and capillary fragility and has considerable antioxidant activity. It is also used to treat eye strain, diabetic retinopathy, and enhance wound healing when applied locally. When will it start to work?
It appears to relieve symptoms of venous insufficiency within 10 days and eye strain within 5 weeks. Are there any safety issues?
Research suggests it ¡swell tolerated and generally safe; however, people taking anticoagulant medicines should refer to their healthcare professional before taking this substance.
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