Baical skullcap contains numerous flavonoids and their glycosides. The main flavonoids are baicalin and its aglycone, baicalein and wogonin. Resin and tannins are also present.
Baical also contains melatonin. It has been shown that dietary melatonin directly contributes to the circulating level of the hormone. The clinical effects of plant-derived melatonin remains to be investigated (Hardeland & Poeggeler 2003). Baicalin itself is poorly absorbed from the gut, but is hydrolysed to its aglycone, baicalein, by intestinal bacteria and then restored to its original form from the absorbed baicalein in the body (Akao et al 2000).
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